Kaurenoic Acid Isolated from the Root Bark of Annona senegalensis Induces Cytotoxic and Antiproliferative Effects against PANC-1 and HeLa cells
نویسندگان
چکیده
منابع مشابه
Anticonvulsant effect of kaurenoic acid isolated from the root bark of Annona senegalensis.
CONTEXT The herbal preparations of Annona senegalensis Pers. (Annonaceae) root bark are used in Nigerian ethnomedicine for the treatment of epilepsy and febrile seizures. The scientific evidence for this effect has been reported. OBJECTIVE The aim of this study was to identify and characterize the active constituent responsible for the anticonvulsant effect. MATERIALS AND METHODS Bioactive-...
متن کاملAntimicrobial Effects of a Lipophilic Fraction and Kaurenoic Acid Isolated from the Root Bark Extracts of Annona senegalensis
Root bark preparation of Annona senegalensis Pers. (Annonaceae) is used in Nigerian ethnomedicine for treatment of infectious diseases. Extraction of the A. senegalensis powdered root bark with methanol-methylene chloride (1 : 1) mixture yielded the methanol-methylene extract (MME) which was fractionated to obtain the ethyl acetate fraction (EF). The EF on further fractionation gave two active ...
متن کاملAnticonvulsant Activity of Aqueous Root Extract of Annona Senegalensis Pers
Objective: Annona senegalenesis Pers is a sprawling shrub belonging to the family Annonaceae, and is mainly used in ethnomedicine. The use of decoction of A. senegalenesis is very prominent in the management of various conditions ranging from bacterial infection, worm infestation, snake bites, pyrexia and febrile convulsion in folk medicine. Methods: The investigation on anti...
متن کاملThe epimer of kaurenoic acid from Croton antisyphiliticus is cytotoxic toward B-16 and HeLa tumor cells through apoptosis induction.
Cancer has become the leading cause of death in developing countries due to increased life expectancy of the population and changes in lifestyle. Studies on active principles of plant have motivated researchers to develop new antitumor agents that are specific and effective for treatment of neoplasms. Kaurane diterpenes are considered important compounds in the development of new and highly eff...
متن کاملCytotoxic and apoptotic effects of root extract and tanshinones isolated from Perovskia abrotanoides Kar
Objective(s):Perovskia abrotanoides Kar., from family Lamiaceae, is a little known medicinal plant growing in various regions of Iran. In the present study, cryptotanshinone (CT), tanshinone 2A (Tan2A), and hydroxycryptotanshinone (HCT) were isolated and purified from the roots of P. abrotanoides. In addition, cytotoxic and apoptotic effects of total root extract (TE) and three purified tanshin...
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ژورنال
عنوان ژورنال: European Journal of Medicinal Plants
سال: 2014
ISSN: 2231-0894
DOI: 10.9734/ejmp/2014/6926